Transmissible mink encephalopathy: pathogenesis and nature of the aetiological agent.
نویسنده
چکیده
A number of specific encephalopathies of mink are recognized, eg, Chasteks' paralysis-an haemorrhagic destruction of grey matter associated with hypothiaminosis (Innes and Saunders, 1962) and metachromatic leucodystrophy which has a sublethal autosomal recessive transmission (Brander and Palludan, 1965). The present paper concerns a disease characterized by spongy transformation of grey matter which, experimentally, may be readily transmitted to healthy mink by the injection of suspensions of tissues from affected animals. To distinguish this condition from others, Marsh, Burger, and Hanson (1969) have proposed the name 'transmissible mink encephalopathy'. The disease conforms to the criteria for 'slow infections' (Sigurdsson, 1954) and has features in common with scrapie in sheep, kuru, and in man CreutzfeldtJakob disease.
منابع مشابه
Failure to demonstrate specific antibody in transmissible mink encephalopathy.
Attempts to demonstrate specific serum antibody or immune complexes in the brains of mink affected with transmissible mink encephalopathy were unsuccessful with serum neutralization and immunofluorescent procedures. These data may be significant, considering the unusual nature of the disease and the biochemical properties of the etiological agent.
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عنوان ژورنال:
- Journal of clinical pathology. Supplement
دوره 6 شماره
صفحات -
تاریخ انتشار 1972